SELECTED PUBLICATIONS

Hinther, A., Bromba, C.M., Wulff, J.E., and Helbing, C.C. 2011. Effects of triclocarban, triclosan, and methyl-triclosan on thyroid hormone action and stress in frog and mammalian culture systems. Environmental Science & Technology, 44: 5395-402.

Veldhoen, N., Kobylarz, M., Lowe, C.J., Meloche, L., de Bruyn, A., and Helbing, C.C. 2011. Relationship between mRNA biomarker candidates and location near a marine municipal wastewater outfall in the benthic indicator species Modiolous modiolous (L.). Aquatic Toxicology, 105: 119-26.

Helbing, C.C., Propper, C. and Veldhoen, N. 2011. Triclosan affects the thyroid axis of amphibians. Letter to Editor. Toxicological Science, Aug 18 Epub ahead of print PMID: 21852691.

Helbing, C.C., Wulff, J.E., Bromba, C.M., Hinther, A., and Veldhoen, N. 2011. Reply to comment on “Effects of triclocarban, triclosan, and methyl-triclosan on thyroid hormone action and stress in frog and mammalian culture systems”. Environmental Science & Technology, 45: 7600-1.

Gunderson, M.P., Veldhoen, N., Skirrow, R.C., Macnab, M.K., Ding, W., van Aggelen, G., and Helbing, C.C. 2011. Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana). Aquatic Toxicology, 102: 31-8.

Helbing, C.C., van Aggelen, G. and Veldhoen, N. 2011. Triclosan affects thyroid hormone-dependent metamorphosis in anurans. Letter to Editor. Toxicological Science, 119: 417-8.

Hinther, A., Vawda, S., Skirrow, R.C., Veldhoen, N., Collins, P., Cullen, J.T., van Aggelen, G., and Helbing, C.C. 2010. Nanometals induce stress and alter thyroid hormone action in amphibian at or below North American water quality guidelines. Environmental Science & Technology, 44: 8314-8321.

Helbing, C.C., Maher, S.K., Han, J., Gunderson, M.P., and Borchers, C. 2010. Peering into molecular mechanisms of action with frogSCOPE. General and Comparative Endocrinology, 168: 190-198.

Hinther, A., Domanski, D., Vawda, S., and Helbing, C.C. 2010. C-fin: A cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals. Environmental Toxicology and Chemistry, 29: 380-388.

Veldhoen, N., Ikonomou, M.G., Dubetz, C., MacPherson, N., Sampson, T., Kelly, B.C. and Helbing, C.C. 2010. Gene expression profiling and environmental contaminant assessment of migrating Pacific salmon in the Fraser River watershed of British Columbia. Aquatic Toxicology, 97: 212-225.

Esterhuyse, M.M., Helbing, C.C., and van Wyk, J.H. 2010. Isolation and characterization of three estrogen receptor transcripts in Oreochromis mossambicus (Peters). J. Steroid Biochem. Mol. Biol., 119: 26-34.

Dryhurst, D., Ishibashi, T., Rose, K.L., Eirin-Lopez, J.M., McDonald, D., Silva-Moreno, B., Veldhoen, N., Helbing, C.C., Hendzel, M.J., Shabanowitz, J., Hunt, D.F., and Ausió, J. 2009. Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates. BMC Biology, 7: 86.

Esterhuyse, M.M., Venter, M., Veldhoen, N., Helbing, C.C., and J.H. van Wyk. 2009. Characterization of vtg-1 mRNA expression during ontogeny in Oreochromis mossambicus (PETERS). J. Steroid Biochem. Mol. Biol., 119: 26-34.

Van Aggelen, G., Ankley, G., Baldwin, W., Bearden, D., Benson, W., Chipman, J., Collette, T., Craft, J., Denslow, N., Embry, M., Falciani, F., George, S., Helbing, C., Hoekstra, P., Iguchi, T., Kagami, Y., Katsiadaki, I., Kille, P., Liu, L., Lord, P., McIntyre, T., O’Neill, A., Osachoff, H., Perkins, E., Santos, E., Skirrow, R., Snape, J., Tyler, C., Versteeg, D., Viant, M., Volz, D., Williams, T. and Yu, L. 2009. Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: Hurdles, achievements and future outlook. Environmental Health Perspectives, 18:1-5.

Veldhoen, N., Lowe, C., Davis, C., Mazumder, A. and Helbing, C.C. 2009. Gene expression profiling in the deep water horse mussel Modiolus modiolus (L.) located near a marine municipal wastewater outfall. Aquatic Toxicology, 93: 116-124.

Maher, S.K. and C.C. Helbing. 2009. Modulators of Inhibitor of Growth (ING) Family Expression in Development and Disease. Current Drug Targets, 10: 392-405.

Skirrow, R.C., Veldhoen, N., Domanski, D. and C.C. Helbing. 2008. Roscovitine inhibits thyroid hormone-induced tail regression of the frog tadpole and reveals a role for phosphorylation in the establishment of the gene expression program. Developmental Dynamics, 237: 3787-3797.

Esterhuyse, M.M., Helbing, C.C., and J.H. van Wyk. 2008. Temporal expression of two cytochrome P450 aromatase isoforms during development in Oreochromis mossambicus, in association with histological development. Comparative Biochemistry and Physiology Part D, 3: 297-306.

Wagner, M.J. and C.C. Helbing. Characterization of the Inhibitor of Growth ING1 and ING2 gene promoters in Xenopus laevis. 2008. Biochemica Biophysica Acta – Gene Regulatory Mechanisms, 1779:152-163.

Esterhuyse, M.M., Helbing, C.C., and J.H. van Wyk. 2008. Temporal expression of two cytochrome P450 aromatase isoforms during development in Oreochromis mossambicus, in association with histological development. Comparative Biochemistry and Physiology Part D, in press.

Walzak, A.A., Veldhoen, N., Feng, X., Riabowol, K., and C. C. Helbing. 2008. Expression profiles of mRNA transcript variants encoding the human Inhibitor of Growth tumour suppressor gene family in normal and neoplastic tissues. Experimental Cell Research, 314:273-85.

Domanski, D. and C.C. Helbing. 2007. Analysis of the Rana catesbeiana tadpole tail fin proteome and phosphoproteome during T3-induced apoptosis: Identification of a novel type I keratin. BMC Developmental Biology, 7:94.

Helbing, C.C., Bailey, C.M., Ji, L., Gunderson, M.P, Zhang, F., Veldhoen, N., Mu, R., Lesperance, M., Holcombe, G.W., Kosian, P.A., Tietge, J., Korte, J.J., and S.J. Degitz. 2007. Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay Part 1: Effects on the brain. Aquatic Toxicology, 82, 227-241.

Helbing, C.C., Ji, L., Bailey, C.M., Veldhoen, N., Zhang, F., Holcombe, G.A., Kosian, P.A., Tietge, J., Korte, J.J., and S. J. Degitz. 2007. Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay Part 2: Effects on the tail and hindlimb. Aquatic Toxicology, 82, 215-226.

Ji, L., Domanski, D., Skirrow, R.C., and C. C. Helbing. 2007. Genistein prevents protein kinase C and thyroid hormone receptor alpha phosphorylation during thyroid hormone-dependent tail regression of Rana catesbeiana tadpoles. Developmental Dynamics, 236, 777-790.

Skirrow, R.C. and C.C. Helbing. 2007. Decreased cyclin dependent kinase activity promotes thyroid hormone-dependent tail regression in Rana catesbeiana. Cell Tissue Research, 328, 281-289.

Helbing, C.C., Crump, K., Bailey, C.M., Kohno, S., Veldhoen, N., Song, Y., Bermudez, D.S., Bryan, T., Ausió, J. and L.J. Guillette, Jr. 2007. Characterization of Inhibitor of Growth 2 tumor suppressor in Alligator mississippiensis, its conservation in Archosauria, and response to thyroid stimulating hormone. Comparative Biochemistry and Physiology B, 146, 279-288.

Veldhoen, N., Skirrow, R.C., Osachoff, H., Wigmore, H., Clapson, D.J., Gunderson, M.P., Van Aggelen, G., and Helbing, C.C. 2006. The bactericidal agent Triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquatic Toxicology, 80, 217-227.

Helbing, C.C., Ovaska, K., and L. Ji. 2006. Evaluation of the effect of acetochlor on thyroid hormone receptor gene expression in the brain and behavior of Rana catesbeiana tadpoles. Aquatic Toxicology, 80, 42-51.

Veldhoen, N., Boggs, A., Walzak, K. and C. C. Helbing. 2006. Exposure to tetrabromobisphenol-A alters TH-Associated gene expression and tadpole metamorphosis in the Pacific tree frog Pseudacris regilla. Aquatic Toxicology, 78, 292-302.

Tabuchi, M., Veldhoen, N., Dangerfield, N., Jeffries, S., Helbing, C.C. and P.S. Ross. 2006. PCB-related alteration of thyroid hormone and their receptor alpha gene expression in free-ranging harbor seals (Phoca vitulina). Environmental Health Perspectives, 114, 1024–1031.

Veldhoen, K., Allison, W.T., Veldhoen, N., Anholt, B.R., Helbing, C.C. and Hawryshyn, C.W. 2006. Spatio-temporal characterization of retinal opsin gene expression during thyroid hormone-induced and natural development of rainbow trout. Visual Neuroscience 23, 169-179.

Veldhoen, N., Skirrow, R.C., Ji, L., Domanski, D., Bonfield, E.R., Bailey, C.M. and C.C. Helbing. 2006. Use of heterologous cDNA arrays and organ culture in the detection of thyroid hormone-dependent responses in sentinel frog species. Comparative Biochemistry and Physiology D, 1, 187-199.

Zhang, F., Degitz, S.J., Holcombe, G.W., Kosian, P.A., Tietge, J., Veldhoen, N., and C.C. Helbing. 2006. Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors. Aquatic Toxicology 76, 24-36.

Wagner, M.J. and C.C. Helbing. 2005. Multiple variants of ING1 and 2 are differentially expressed and thyroid hormone-responsive in Xenopus laevis. General and Comparative Endocrinology 144:38-50.

He, G.H.Y., Helbing, C.C., Wagner, M.J., Sensen, C.W. and K. Riabowol. 2005. Phylogenetic analysis of the ING family of PHD finger proteins. Molecular Biology and Evolution 22, 104-116.

Veldhoen, N. and Helbing, C. 2005. Monitoring gene expression on Rana catesbeiana tadpoles using a tail fin biopsy technique and its application to the detection of environmental endocrine disruptor effects, in: Techniques in Aquatic Toxicology – Vol. 2 (G. Ostrander, ed.), pp. 315-327, Taylor & Francis, Boca Raton, FL.

Katsu, Y., Bermudez, D.S., Braun, E., Helbing, C., Miyagawa, S., Gunderson, M.P., Kohno, S., Bryan, T.A., Guillette Jr., L.J. and T. Iguchi. 2004. Molecular cloning of the estrogen and progesterone receptors of the American alligator. General and Comparative Endocrinology 136, 122-133.

Howe, C.M., Berrill, M., Pauli, B.D., Helbing, C.C., Werry, K. and Veldhoen, N. 2004. Toxicity of glyphosate-based pesticides to four North American frog species. Environmental Toxicology and Chemistry 23, 1928-1938.

Helbing, C.C., Werry, K., Crump, D., Domanski, D., Veldhoen, N. and Bailey, C.M. 2003. Expression profiles of novel thyroid hormone-responsive genes and proteins in the tail of Xenopus laevis tadpoles undergoing precocious metamorphosis. Molecular Endocrinology 17, 1395-1403.

Crump, D., Werry, K., Veldhoen, N., van Aggelen, G. and C.C. Helbing. 2002. Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus laevis. Environmental Health Perspectives 110, 1199-1205.

Veldhoen, N., Crump, D., Werry, K. and C.C. Helbing. 2002. Distinctive gene profiles occur at key points during natural metamorphosis in the Xenopus laevis tadpole tail. Developmental Dynamics 225, 457-468.

Wagner, M.J., Gogela-Spehar, M., Skirrow, R.C., Johnston, R.N., Riabowol, K.T. and Helbing, C.C. 2001. Expression of novel ING variants is regulated by thyroid hormone in the Xenopus laevis tadpole. J Biol Chemistry 276, 47013-47020.

Veldhoen, N. and C. Helbing, 2001. Detection of environmental endocrine disruptor effects on gene expression in live Rana catesbeiana tadpoles using a tail fin biopsy technique. Environmental Toxicology and Chemistry 20, 2704-2708.

Last Update, Sept 2011