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Nashmi Neurobiology Lab at the University of Victoria
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Welcome to Dr. Nashmi's Neuro Lab

Our goal is to understand the role nicotinic receptors play in modulating neurotransmission in the central nervous system and to elucidate their role in a variety of nervous system disorders.

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A major interest in the lab is to examine the role of nicotinic receptors in modulating neurotransmission in the CNS. We employ a variety of techniques including patch-clamp electrophysiology and optogenetics. We are also interested in imaging and quantifying the subcellular localization of nicotinic receptors in specific neural circuits using a combination of approaches, including mouse genetic engineering to examine fluorescently tagged receptors in knock-in mice and spectral confocal imaging.

A significant effort in the lab is devoted to understanding signalling pathways and molecules that interact with nicotinic receptors and alter their function and expression. The spectroscopic technique, Förster resonance energy transfer (FRET), as well as proteomic approaches will be used to examine the protein-protein interactions and post-translational modifications.

We are interested in how dysregulation and dysfunction of nicotinic receptors mediate specific nervous system disorders such as nicotine addiction. Specifically, we examine for altered cholinergic neurotransmission, expression and function of nicotinic receptors in specific neurons in the brain. We are also collaborating with Dr. Kerry Delaney to examine altered nicotinic signalling in a mouse model of Rett syndrome. Nicotinic receptor dysfunction have been implicated in other neurological disorders including epilepsy, ADHD, schizophrenia, Alzheimer's disease, and Parkinson's disease.

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Recent Publications

Current Biology 2017

Behavioral Brain Res 2017

Neuropharmacology 2016

All Publications

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Come join our team. We have openings for bright and enthusiastic students at the MSc or PhD level in the Neuroscience Graduate Program at UVic.

Please contact Dr. Raad Nashmi through any of the channels listed below:


(250) 721 6169

University of Victoria
Department of Biology
Petch Building 168
3800 Finnerty Road
Victoria, BC V8P 5C2