Our goal is to understand the role nicotinic receptors play in modulating neurotransmission in the central nervous system and to elucidate their role in a variety of nervous system disorders.
A major interest in the lab is to examine the role of nicotinic receptors in modulating neurotransmission in the CNS. We employ a variety of techniques including patch-clamp electrophysiology and optogenetics. We are also interested in imaging and quantifying the subcellular localization of nicotinic receptors in specific neural circuits using a combination of approaches, including mouse genetic engineering to examine fluorescently tagged receptors in knock-in mice and spectral confocal imaging.
A significant effort in the lab is devoted to understanding signalling pathways and molecules that interact with nicotinic receptors and alter their function and expression. The spectroscopic technique, Förster resonance energy transfer (FRET), as well as proteomic approaches will be used to examine the protein-protein interactions and post-translational modifications.
We are interested in how dysregulation and dysfunction of nicotinic receptors mediate specific nervous system disorders such as nicotine addiction. Specifically, we examine for altered cholinergic neurotransmission, expression and function of nicotinic receptors in specific neurons in the brain. We are also collaborating with Dr. Kerry Delaney to examine altered nicotinic signalling in a mouse model of Rett syndrome. Nicotinic receptor dysfunction have been implicated in other neurological disorders including epilepsy, ADHD, schizophrenia, Alzheimer's disease, and Parkinson's disease.
Postdoctorate: California Institute of Technology
PhD: University of Toronto
Dr. Patrick Walter
Alumni MSc Student
Currently a PhD student at
U of British Columbia
Alumni MSc Student
Currently a Registered Nurse
Alumni PhD Student
Currently Assistant Professor
BITS University, India
Dr. Nashmi currently teaches the following courses:
Come join our team. We have openings for bright and enthusiastic students at the MSc or PhD level in the Neuroscience Graduate Program at UVic.
Please contact Dr. Raad Nashmi through any of the channels listed below: