Chem 590
Course coordinator
Home
Modules
1. Structure-based
inhibitor design
2. Magnetism
3. Mass
spectrometry
4. EPR
spectroscopy
5. Heteronuclear
NMR
6. Metals
in organic synthesis
7. X-ray
crystallography
8. Practical
computer programming for chemists
Syllabus
Structure-based inhibitor design
Instructor: Fraser Hof
Content: The lessons of this course will be derived from protein-drug
interactions, but this module is intended to lay a practical
foundation for anyone interested in the design of molecular structure
and function in ANY context, even those not involving proteins or drugs.
Students will develop a basic understanding of the conformational
effects and weak interactions that govern small molecule–protein
binding using software that is readily available in our department.
The use of the Cambridge Structural Database (CSD) for structural and
conformational surveys will be discussed in lecture, and the use of
the free molecular modeling software MOLOC will be taught using a
practical exercise.
Delivery: Fall 2007, exact timing to be determined in consultation
with enrolled students
Assessment: A brief written review of a recently published article selected in consultation with the instructor.
© JS McIndoe, Department of Chemistry, University of Victoria. Updated 15 August, 2007.