Chem 590

Course coordinator
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Modules
1. Structure-based inhibitor design
2. Magnetism
3. Mass spectrometry
4. EPR spectroscopy
5. Heteronuclear NMR
6. Metals in organic synthesis
7. X-ray crystallography
8. Practical computer programming for chemists
Syllabus

Transition metals in organic synthesis

Instructor: David Berg

Content: This course will focus on the catalytic and stoichiometric uses of transition metal complexes in organic synthesis with a strong emphasis on molecular, rather than polymeric, organic products. A major section will focus on the formation of new C-C bonds and will include reactions such as hydroformylation, hydrometallations, cyclopropanation, alkene ring closing metathesis, Pd-catalyzed couplings and Pauson-Khand type reactions. A smaller section will deal with metal-based oxidations and reductions including hydrogenations, epoxidation and aminohydroxylations. The course will emphasize the synthetic utility and mechanistic underpinnings of these reactions.

Delivery: Five 90-minute lectures offered in January or February 2008. Lecture times will probably be in the early afternoon, depending on the availability of lecture rooms.

Assessment: One 1-hour written examination.